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Chapter 15 Brain Tumors and the Lynch Syndrome

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Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is e...

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Autore principale: Peltomäki, Päivi (auth)
Altri autori: Gylling, Annette (auth)
Natura: Elettronico Capitolo di libro
Lingua:inglese
Pubblicazione: InTechOpen 2011
Soggetti:
Science: general issues
brain tumors
lynch syndrome
Colorectal cancer
DNA methylation
DNA mismatch repair
Gene
Glioblastoma
Glioma
Hereditary nonpolyposis colorectal cancer
Mutation
Neoplasm
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Riassunto:Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).
ISBN:21293
Accesso:Open Access

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