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Chapter Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry

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A characteristic of many proteoforms, derived from a single gene, is their similarity regarding the composition of atoms, making their analysis very challenging. Many overexpressed recombinant proteins are strongly associated with this problem, especially recombinant therapeutic glycoproteins from l...

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Bibliographic Details
Main Author: Heikaus, Laura (auth)
Other Authors: Schlüter, Hartmut (auth), Nurul Hidayah, Siti (auth), Gaikwad, Manasi (auth)
Format: Electronic Book Chapter
Language:English
Published: InTechOpen 2019
Subjects:
Biochemistry
proteoforms, top-down mass spectrometry, therapeutic proteins, liquid chromatography, protein purification parameter screening, displacement chromatography
Online Access:OAPEN Library: download the publication
OAPEN Library: description of the publication
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