Electrophysiological Profiling of Depression in the Elderly

• 主要な著者: Jenny L Patterson (著者), J. Bruce Barber (著者), Daniel W. O Connor (著者), Samia R Toukhsati (著者)
• フォーマット: 図書
• 出版事項: Archives of Depression and Anxiety - Peertechz Publications, 2016-07-23.
• 主題: Research Article
• オンライン･アクセス: Connect to this object online.

要約

<p>Frontostriatal system functioning has been  proposed to underpin  performance on executive functioning tasks; these structures are abnormally activated in adults with depression. In this study, the P200 and P300 event-related potentials (ERPs) were elicited during a classic two-tone auditory oddball task to compare the electrophysiological profiles of elderly people (N = 54; Mean age = 85.46 ± 6.21) diagnosed with clinical depression ( n  = 17), subthreshold depression ( n  = 25) or no depression ( n  = 12). The P200 results revealed higher amplitude and significantly longer latencies in depressed groups relative to non-depressed  participants. Higher P300 amplitude, but shorter latencies, were observed  in depressed relative to non-depressed participants.  Findings  are  discussed  in  terms  of cognitive information processing models of ERPs and the potential for non-cognitive factors to impact on the resulting electrophysiological profile. </p>

DOI

10.17352/2455-5460.000012