Anti-VEGF Therapy Induces Proteinuria through Endothelial Disorganization Leading to Nephrin Decrease in Podocytes

• Main Authors: Marianne Terrasse (Author), Florence Jouan (Author), Thibault Dolley-Hitze (Author), Yannick Arlot-Bonnemains (Author), Marc-Antoine (Author), Nathalie Rioux-Leclercq (Author), Nolwenn Lorcy (Author), Cécile Vigneau (Author)
• Format: Book
• Published: International Journal of Immunotherapy and Cancer Research - Peertechz Publications, 2015-10-28.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p><strong>Background:</strong> VEGF is involved in cancer development by stimulating neo-angiogenesis and tumor proliferation. Anti-angiogenic therapies, especially tyrosine kinase inhibitors such as sunitinib, have significantly improved cancer prognosis. Nevertheless, renal side...