Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers
<p>Objectives: This study aimed to develop a model of the relationship between inflammatory cytokine and/or vascular adhesion molecule levels and clinical symptoms in individuals exposed to lead (Pb), manganese (Mn) or both (Pb+Mn).</p><p>Methods: The study included 104 male worker...
Saved in:
Main Authors: | , , , , , , |
---|---|
Format: | Book |
Published: |
International Journal of Immunotherapy and Cancer Research - Peertechz Publications,
2019-12-24.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
LEADER | 00000 am a22000003u 4500 | ||
---|---|---|---|
001 | peertech__10_17352_2455-8591_000020 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Ozgur Oztan |e author |
700 | 1 | 0 | |a Vugar Ali Turksoy |e author |
700 | 1 | 0 | |a Iskender Samet Daltaban |e author |
700 | 1 | 0 | |a Meside Gunduzoz |e author |
700 | 1 | 0 | |a Lutfiye Tutkun |e author |
700 | 1 | 0 | |a Servet Birgin Iritas |e author |
700 | 1 | 0 | |a Hakan AK |e author |
245 | 0 | 0 | |a Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers |
260 | |b International Journal of Immunotherapy and Cancer Research - Peertechz Publications, |c 2019-12-24. | ||
520 | |a <p>Objectives: This study aimed to develop a model of the relationship between inflammatory cytokine and/or vascular adhesion molecule levels and clinical symptoms in individuals exposed to lead (Pb), manganese (Mn) or both (Pb+Mn).</p><p>Methods: The study included 104 male workers exposed to metals for different durations in a factory setting (Mn-, Pb- and Pb+Mn-exposed groups) and 76 non-exposed male workers (control group). Interleukin (IL)-6, IL-10, Tumor Necrosis Factor (TNF)-α, soluble (s)E-selectin, and Vascular Cell Adhesion protein (VCAM)-1 levels were analyzed using enzyme-linked immunosorbent assays. Mn and Pb levels were determined using inductively coupled plasma mass spectrometry.</p><p>Results: Significant intergroup differences were observed in the levels of IL-6, IL-10, TNF-α, and sE-selectin (p<0.01 for all), but not VCAM-1 (p=0.298). Fatigue was the most frequent symptom in all groups (25.7%, 37.1%, and 44.1%, respectively). Other symptoms included tremor and anxiety in the Mn-exposed group (5.7%), and tremor and paresthesia in the Pb-exposed (14.7%) and Pb+Mn-exposed groups (20.6%).</p><p>Conclusions: The correlation between increased biomarker levels and clinical symptoms suggests a close relationship between inflammation and neurotoxicity. This relationship not only explains the effect of the former on the latter but also provides a clinical model for the early diagnosis of neuroinflammation.</p> | ||
540 | |a Copyright © Ozgur Oztan et al. | ||
546 | |a en | ||
655 | 7 | |a Research Article |2 local | |
856 | 4 | 1 | |u https://doi.org/10.17352/2455-8591.000020 |z Connect to this object online. |