Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers

• Những tác giả chính: Ozgur Oztan (Tác giả), Vugar Ali Turksoy (Tác giả), Iskender Samet Daltaban (Tác giả), Meside Gunduzoz (Tác giả), Lutfiye Tutkun (Tác giả), Servet Birgin Iritas (Tác giả), Hakan AK (Tác giả)
• Định dạng: Sách
• Được phát hành: International Journal of Immunotherapy and Cancer Research - Peertechz Publications, 2019-12-24.
• Những chủ đề: Research Article
• Truy cập trực tuyến: Connect to this object online.

<p>Objectives: This study aimed to develop a model of the relationship between inflammatory cytokine and/or vascular adhesion molecule levels and clinical symptoms in individuals exposed to lead (Pb), manganese (Mn) or both (Pb+Mn).</p><p>Methods: The study included 104 male workers exposed to metals for different durations in a factory setting (Mn-, Pb- and Pb+Mn-exposed groups) and 76 non-exposed male workers (control group). Interleukin (IL)-6, IL-10, Tumor Necrosis Factor (TNF)-α, soluble (s)E-selectin, and Vascular Cell Adhesion protein (VCAM)-1 levels were analyzed using enzyme-linked immunosorbent assays. Mn and Pb levels were determined using inductively coupled plasma mass spectrometry.</p><p>Results: Significant intergroup differences were observed in the levels of IL-6, IL-10, TNF-α, and sE-selectin (p<0.01 for all), but not VCAM-1 (p=0.298). Fatigue was the most frequent symptom in all groups (25.7%, 37.1%, and 44.1%, respectively). Other symptoms included tremor and anxiety in the Mn-exposed group (5.7%), and tremor and paresthesia in the Pb-exposed (14.7%) and Pb+Mn-exposed groups (20.6%).</p><p>Conclusions: The correlation between increased biomarker levels and clinical symptoms suggests a close relationship between inflammation and neurotoxicity. This relationship not only explains the effect of the former on the latter but also provides a clinical model for the early diagnosis of neuroinflammation.</p>