Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner

• Main Authors: Kosuke Tanaka (Author), Kana Mizuno (Author), Chika Natsume (Author), Misaki Takanishi (Author), Yuki Shimada (Author), Ryo Saito (Author), Norihisa Fujita (Author), Takashi Fujita (Author)
• Format: Book
• Published: International Journal of Dermatology and Clinical Research - Peertechz Publications, 2019-02-02.
• Subjects: Research Article
• Online Access: Connect to this object online.

<p>Nε-(carboxymethyl) lysine (CML), an advanced glycation end product (AGE), is an aging factor produced by glycation of protein. Higher levels of AGE in skin tissue are related to skin elasticity, but how CML that has accumulated in the skin affects hair follicle formation is unclear. This st...