Direct action antivirals are effective in the total eradication of HCV in renal transplants

• Main Authors: Teresa Olea (Author), Inmaculada Castillo (Author), Carlos Jiménez (Author), Javier Bartolomé (Author), María José Santana (Author), JA Quiroga (Author), Vicente Carreño (Author), Rafael Selgas (Author)
• Format: Book
• Published: Annals of Antivirals and Antiretrovirals - Peertechz Publications, 2019-07-22.
• Subjects: Research Article
• Online Access: Connect to this object online.

Summary

<p><strong>Introduction</strong>: The main objective of our study was to analyze the effectiveness of antiviral treatment (conventional or with direct-acting antivirals (DAA)) for total eradication of Hepatitis C Virus (HCV) in kidney transplant (KT) recipients. DAA are known drugs that are approved by FDA for clinical and preclinical</p><p>investigations. The effi cacy was analyzed by testing for the presence of HCV- ribonucleic acid (RNA) in the pellets obtained after ultracentrifugation of follow-up plasma samples and in peripheral blood mononuclear cells (PBMC) from patients with HCV infection who had achieved a sustained virological response (SVR). The safety, and the renal and hepatic repercussions of the antiviral treatment were also evaluated.</p>

DOI

10.17352/aaa.000005