Autoimmune hepatitis associated Hepatitis C virus infection treated with fi rst generation direct-acting antivirals

• Huvudskapare: Juan Diego Castro Limo (Författare, medförfattare), Tomas Artaza Varasa (Författare, medförfattare), Maria Recuero Pradillo (Författare, medförfattare), Marta Romero-Gutierrez (Författare, medförfattare), Ana Zaida Gomez Moreno (Författare, medförfattare), Juan Jose Sanchez Ruano (Författare, medförfattare), Carlos San Roman Gutierrez (Författare, medförfattare), Pablo Munoz Gomez (Författare, medförfattare), Rafael Gomez Rodríguez (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Annals of Antivirals and Antiretrovirals - Peertechz Publications, 2019-10-04.
• Ämnen: Case Report
• Länkar: Connect to this object online.

Sammanfattning

<p>The hepatitis C virus (HCV) infection has been associated with autoimmune diseases, probably due to the interaction between HCV E2 envelope protein and CD-81 receptor of B lymphocyte and thus, can infl uence the pathogenesis of autoimmune liver diseases [1,2]. Therefore, it seems reasonable to consider the benefi cial effect of direct-acting antivirals (DAAs) for HCV in patients with chronic HCV infection and autoimmune hepatitis (HAI), although evidence is scarce. We report the case of an HCV-infected patient who developed an HAI triggered by interferon and since then has been treated with DAAs improving liver function and maintaining sustained virologic response (SVR), without immunosuppressive treatment nowadays.</p>

DOI

10.17352/aaa.000006