Synthesis, characterization and cytotoxic activity of betulinic acid glucosides against human myeloid leukemia and human T-4 lymphoblastoid cell lines / Mohd Tajudin Mohd Ali and Nurhana Faujan
Glycosylation of betulinic acid with B-D-glucose-pentaacetate was successfully synthesized in the presence of boron trifluoro etherate (BF3.Et2O) in pyridine to give betulinic acid bisglucoside in 92.8% yield. Further treatment of bisglucosides with methanol and sodium metal produced high polarity b...
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| Format: | Book |
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2016-06.
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| Summary: | Glycosylation of betulinic acid with B-D-glucose-pentaacetate was successfully synthesized in the presence of boron trifluoro etherate (BF3.Et2O) in pyridine to give betulinic acid bisglucoside in 92.8% yield. Further treatment of bisglucosides with methanol and sodium metal produced high polarity betulinic acid glucoside with 45% yield. Evaluation of human myeloid leukemia cell (HL60) and human T4-lymphoblastoid cell (CEMSS) activities with both synthesized compounds revealed that both compounds were less potent compared to betulinic acid itself but their water solubility were slightly increase. |
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| Item Description: | https://ir.uitm.edu.my/id/eprint/41504/1/41504.pdf |