Synthesis, characterization and cytotoxic activity of betulinic acid glucosides against human myeloid leukemia and human T-4 lymphoblastoid cell lines / Mohd Tajudin Mohd Ali and Nurhana Faujan
Glycosylation of betulinic acid with B-D-glucose-pentaacetate was successfully synthesized in the presence of boron trifluoro etherate (BF3.Et2O) in pyridine to give betulinic acid bisglucoside in 92.8% yield. Further treatment of bisglucosides with methanol and sodium metal produced high polarity b...
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2016-06.
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| 001 | repouitm_41504 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mohd Ali, Mohd Tajudin |e author |
| 700 | 1 | 0 | |a Faujan, Nurhana |e author |
| 245 | 0 | 0 | |a Synthesis, characterization and cytotoxic activity of betulinic acid glucosides against human myeloid leukemia and human T-4 lymphoblastoid cell lines / Mohd Tajudin Mohd Ali and Nurhana Faujan |
| 260 | |c 2016-06. | ||
| 500 | |a https://ir.uitm.edu.my/id/eprint/41504/1/41504.pdf | ||
| 520 | |a Glycosylation of betulinic acid with B-D-glucose-pentaacetate was successfully synthesized in the presence of boron trifluoro etherate (BF3.Et2O) in pyridine to give betulinic acid bisglucoside in 92.8% yield. Further treatment of bisglucosides with methanol and sodium metal produced high polarity betulinic acid glucoside with 45% yield. Evaluation of human myeloid leukemia cell (HL60) and human T4-lymphoblastoid cell (CEMSS) activities with both synthesized compounds revealed that both compounds were less potent compared to betulinic acid itself but their water solubility were slightly increase. | ||
| 546 | |a en | ||
| 690 | |a Specialties of internal medicine | ||
| 655 | 7 | |a Article |2 local | |
| 655 | 7 | |a PeerReviewed |2 local | |
| 787 | 0 | |n https://ir.uitm.edu.my/id/eprint/41504/ | |
| 856 | 4 | 1 | |u https://ir.uitm.edu.my/id/eprint/41504/ |z Link Metadata |