Pengaruh Variasi Asam Sitrat, Asam Tartrat Dan Natrium Bikarbonat Dalam Formulasi Granul Effervescent Ekstrak Etanol Daun Ashitaba (Angelica keiskei) Terhadap Sifat Fisik Dan Aktivitas Antioksidan

• Main Authors: Perwitasari, Ery Wijayanti (Author), , Suprapto, M.Sc., Apt (Author), , Rima Munawaroh, M.Sc., Apt (Author)
• Format: Book
• Published: 2016-08.
• Subjects: Thesis; NonPeerReviewed
• Online Access: Connect to this object online
• Notes: https://eprints.ums.ac.id/45821/3/HALAMAN%20DEPAN.pdf; https://eprints.ums.ac.id/45821/4/BAB%20I.pdf; https://eprints.ums.ac.id/45821/6/BAB%20II.pdf; https://eprints.ums.ac.id/45821/7/BAB%20III.pdf; https://eprints.ums.ac.id/45821/8/BAB%20IV.pdf; https://eprints.ums.ac.id/45821/9/DAFTAR%20PUSTAKA.pdf; https://eprints.ums.ac.id/45821/11/LAMPIRAN.pdf; https://eprints.ums.ac.id/45821/12/PERNYATAAN%20PUBLIKASI%20ILMIAH.pdf; https://eprints.ums.ac.id/45821/14/NASKAH%20PUBLIKASI.pdf
• Keywords: RS Pharmacy and materia medica

Angelica keiskei, is a plant that have an antioxidant. In order to increase the comfort and ease of ashitaba consumption, it has been formulated into effervescent granules. The aims of research to determine the effect variation of sodium bicarbonate, citric acid and tartaric acid in effervescent granule formulation of ashitaba ethanol extract that leaves on the physical properties and its antioxidant activity. Effervescent granules were made with three different formulas with a variation of citric acid, tartaric acid and sodium bicarbonate, (1:2:2,5), (1:2:3) and (1:2:3,5) concentration. Ashitaba's of leaves, used as an active compound effervescent granules, was 15 mg. Granules obtained, performed physical properties test, such as organoleptic, moisture content, flowability and dispersion time. Antioxidant activity also tested by DPPH method of extract, vitamin E and granules. The result showed that antioxidant activity of ashitaba extract that leaves and vitamin E have the value of IC50 20,48 µg/mL and 21,34 µg/mL, respectively. Variations of citric acid, tartaric acid and sodium bicarbonate were affected to the physical properties. The more addition of citric acid, the humidity of granules increased. The more addition of tartaric acid, the better flow properties and the more the addition of sodium bicarbonate, the moisture content granules increased. The variation were not influenced the antioxidant activity of samples significantly.