Search Results - Nicholas R Casewell

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite tre... by Stuart Ainsworth, Stefanie K Menzies, Nicholas R Casewell, Robert A Harrison

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Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review. by Michael Abouyannis, Dinesh Aggarwal, David G Lalloo, Nicholas R Casewell, Mainga Hamaluba, Hanif Esmail

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A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite by Laura-Oana Albulescu, Taline Kazandjian, Julien Slagboom, Ben Bruyneel, Stuart Ainsworth, Jaffer Alsolaiss, Simon C. Wagstaff, Gareth Whiteley, Robert A. Harrison, Robert A. Harrison, Chris Ulens, Jeroen Kool, Nicholas R. Casewell, Nicholas R. Casewell

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Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform by Laura-Oana Albulescu, Laura-Oana Albulescu, Adam Westhorpe, Adam Westhorpe, Rachel H. Clare, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O'Neill, Nicholas R. Casewell, Nicholas R. Casewell

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Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of ge... by Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A Harrison, Stuart Ainsworth, Nicholas R Casewell

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Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of ge... by Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A. Harrison, Stuart Ainsworth, Nicholas R. Casewell

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Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically... by Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A Harrison, Stuart Ainsworth, Nicholas R Casewell

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Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms by Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool

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Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy. by R R Senji Laxme, Saurabh Attarde, Suyog Khochare, Vivek Suranse, Gerard Martin, Nicholas R Casewell, Romulus Whitaker, Kartik Sunagar

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High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches. by Julien Slagboom, Marija Mladić, Chunfang Xie, Taline D Kazandjian, Freek Vonk, Govert W Somsen, Nicholas R Casewell, Jeroen Kool

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Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom. by Nicholas R Casewell, Darren A N Cook, Simon C Wagstaff, Abdulsalami Nasidi, Nandul Durfa, Wolfgang Wüster, Robert A Harrison

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Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots. by R R Senji Laxme, Suyog Khochare, Saurabh Attarde, Vivek Suranse, Ashwin Iyer, Nicholas R Casewell, Romulus Whitaker, Gerard Martin, Kartik Sunagar

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Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors by Rachel H. Clare, Rachel H. Clare, Charlotte A. Dawson, Charlotte A. Dawson, Adam Westhorpe, Adam Westhorpe, Laura-Oana Albulescu, Laura-Oana Albulescu, Christopher M. Woodley, Nada Mosallam, Daniel J. W. Chong, Jeroen Kool, Neil G. Berry, Paul M. O'Neill, Nicholas R. Casewell, Nicholas R. Casewell

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Evaluation of the geographical utility of Eastern Russell's viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephr... by Janeyuth Chaisakul, Jaffer Alsolaiss, Mongkon Charoenpitakchai, Kulachet Wiwatwarayos, Nattapon Sookprasert, Robert A Harrison, Narongsak Chaiyabutr, Lawan Chanhome, Choo Hock Tan, Nicholas R Casewell

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Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms. by Matyas A Bittenbinder, Liliana Capinha, Daniel Da Costa Pereira, Julien Slagboom, Bas van de Velde, Nicholas R Casewell, Paul Jennings, Jeroen Kool, Freek J Vonk

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A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. by Michael Abouyannis, Mwanamvua Boga, David Amadi, Nelson Ouma, Amek Nyaguara, Neema Mturi, James A Berkley, Ifedayo M Adetifa, Nicholas R Casewell, David G Lalloo, Mainga Hamaluba

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Correction: Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa. by Robert A Harrison, George O Oluoch, Stuart Ainsworth, Jaffer Alsolaiss, Fiona Bolton, Ana-Silvia Arias, José-María Gutiérrez, Paul Rowley, Stephen Kalya, Hastings Ozwara, Nicholas R Casewell

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Preclinical antivenom-efficacy testing reveals potentially disturbing deficiencies of snakebite treatment capability in East Africa. by Robert A Harrison, George O Oluoch, Stuart Ainsworth, Jaffer Alsolaiss, Fiona Bolton, Ana-Silvia Arias, José-María Gutiérrez, Paul Rowley, Stephen Kalya, Hastings Ozwara, Nicholas R Casewell

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An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity. by Kamille E Krause, Timothy P Jenkins, Carina Skaarup, Mikael Engmark, Nicholas R Casewell, Stuart Ainsworth, Bruno Lomonte, Julián Fernández, José M Gutiérrez, Ole Lund, Andreas H Laustsen

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Stabilising the Integrity of Snake Venom mRNA Stored under Tropical Field Conditions Expands Research Horizons. by Gareth Whiteley, Rhiannon A E Logan, Kam-Yin D Leung, Fiona J Newberry, Paul D Rowley, John P Dunbar, Simon C Wagstaff, Nicholas R Casewell, Robert A Harrison

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