Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia by Xu-Nian Wu, Qian Zhou, Ya-Dan Huang, Xi Xie, Zhe Li, Yinuo Wu, Hai-Bin Luo

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Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer's disease by Chen Zhang, Qian Zhou, Xu-Nian Wu, Ya-Dan Huang, Jie Zhou, Zengwei Lai, Yinuo Wu, Hai-Bin Luo

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Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors by Xu-Nian Wu, Ya-Dan Huang, Jin-Xuan Li, Yan-Fa Yu, Zhou Qian, Chen Zhang, Yinuo Wu, Hai-Bin Luo

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Free energy perturbation (FEP)-guided scaffold hopping by Deyan Wu, Xuehua Zheng, Runduo Liu, Zhe Li, Zan Jiang, Qian Zhou, Yue Huang, Xu-Nian Wu, Chen Zhang, Yi-You Huang, Hai-Bin Luo

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A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities by Guoyou Xie, Xu-Nian Wu, Yuyi Ling, Yalan Rui, Deyan Wu, Jiawang Zhou, Jiexin Li, Shuibin Lin, Qin Peng, Zigang Li, Hongsheng Wang, Hai-Bin Luo

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