Stem Cells and Irradiation

• Daljnji autori: Chapel, Alain (Urednik)
• Format: Elektronički Poglavlje knjige
• Jezik: engleski
• Izdano: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Teme: Research & information: general; Biology, life sciences; human epidermis; keratinocytes; stem cells; precursor cells; low-dose γ irradiation; regeneration; dysplasia; epithelial-to-mesenchymal transition (EMT); ZEB1; experimental radiotherapy; radiobiology; mesenchymal stem cells; cell therapy; exosome; annexin A1; acute respiratory-distress syndrome; COVID-19; local radiation injuries; conditioned medium; cell technologies; X-ray radiation; skin; placenta; Radiation; stem/progenitor cells; organoids; radiation therapy; radiation cystitis; fibrosis; treatment; stem cells therapy; macrophages; mesenchymal stem cell; radiation damage; BCSC; ALDH activity; fractionated dose of γ radiation; radioresistance; ROS; Nrf2; Keap1; miR200a; epithelial-mesenchymal transition (EMT); colorectal cancer; cancer-stem like cells; SOX2; PI3K/AKT; radiation-induced injury; radiotherapy; radiation; mesenchymal; stem cell; extracellular vesicles; micro vesicles; paracrine effect; adipose tissue derived stem cells; n/a
• Online pristup: DOAB: download the publication; DOAB: description of the publication

Sažetak

The main difficulty of radiotherapy is to destroy cancer cells without depletion of healthy tissue. Stem cells and cancers are tightly interrelated. On one hand, radiosensitivity/radioressistance of cancer stem cells affects the radiocurability of tumors. On the other hand, radiosensitivity is responsible for the stem cell depletion of organs at risk exposed to irradiation. Efficient solide cancer destruction is limited by the preservation of organ homeostasis. For this reason, targeted irradiation is an effective cancer therapy, but damage inflicted to normal tissues surrounding the tumor may cause severe complications. The consequences of stem cell depletion of healthy tissue irradiated are acute and chronic radiation diseases. Research on the radiosensitivity of cancer stem cells and adult stem cells associated with tissue regeneration medicine will bring forth the solution for optimal radiocurability associated with long-term patients' quality of life.

Opis fizičkog objekta

1 electronic resource (184 p.)

ISBN

books978-3-0365-6900-0
9783036569017
9783036569000

Pristup

Open Access