Amyloid-beta clearance in Alzheimer's disease

• Main Author: Robert Marr (auth)
• Other Authors: Eliezer Masliah (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Neurosciences; amyloid-beta; Signal Transduction; Proteases; LDL receptors; Clearance; Alzheimer's disease
• Online Access: DOAB: download the publication; DOAB: description of the publication

Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogene...