Antibody Fc Engineering: Towards Better Therapeutics

• Hoofdauteur: Rui Gong (auth)
• Andere auteurs: Tianlei Ying (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Frontiers Media SA 2018
• Reeks: Frontiers Research Topics
• Onderwerpen: Medicine; effector function; Fc receptor; heterodimeric Fc; Fc-fusion protein; monomeric Fc; Monoclonal antibody; Fc engineering
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Monoclonal antibodies and Fc-fusion proteins used clinically are Fc-based therapeutics that grow fastest in the pharmaceutical industry. Since they both contain an Fc fragment, engineering of Fc fragments could be a platform for improving Fc-based drug efficacy. Fc engineering includes various aspec...