Cellular and Phenotypic Plasticity in Cancer

• Main Author: Petranel Theresa Ferrao (auth)
• Other Authors: Andreas Behren (auth), Erik Thompson (auth), Robin Anderson (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; crosstalk; Immune System; Phenotype-switching; plasticity; Exosomes; EMT; Therapy-resistance; signalling; heterogeneity; Cancer
• Online Access: DOAB: download the publication; DOAB: description of the publication

The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and ta...