Cellular and Phenotypic Plasticity in Cancer

• 1. Verfasser: Petranel Theresa Ferrao (auth)
• Weitere Verfasser: Andreas Behren (auth), Erik Thompson (auth), Robin Anderson (auth)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Frontiers Media SA 2015
• Schriftenreihe: Frontiers Research Topics
• Schlagworte: Medicine; crosstalk; Immune System; Phenotype-switching; plasticity; Exosomes; EMT; Therapy-resistance; signalling; heterogeneity; Cancer
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and ta...