Disease and the Hippo Pathway: Cellular and Molecular Mechanisms

• Auteur principal: Hansen, Carsten Gram (auth)
• Format: Électronique Chapitre de livre
• Langue: anglais
• Publié: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Sujets: Biology, life sciences; STRIPAK; skin cancer; n/a; Lats2; transcription; myofibroblast; epigenetic; Hippo; cancer immunity; TAZ; Taz; TAZ (transcriptional co-activator with PDZ-binding motif); adaptive immunity; fibroblasts; innate immunity; LATS; MST (mammalian STE20-like protein kinase); phosphorylation; stem cells; wound healing; signal transduction; angiogenesis; LATS1/2; EMT; protein-protein interactions; structure biology; Hippo pathway; hippo pathway; autoimmunity; Mps one binder; YAP/TAZ; GPCR; fibrosis; MST1/2; YAP (yes-associated protein); YAP; Yap; protein kinase; LATS (large tumor suppressor kinase); peripheral nerve sheath tumor; signal cross-talk; stem cell; skin development; STK38; tumorigenesis; NDR; schwannoma; G protein-coupled receptor; anti-cancer therapy; feedback loops; vascular mimicry; castration resistance; chromatin; Hippo signalling; ECM; MST; prostate cancer; TEAD; cancer; zebrafish
• Accès en ligne: DOAB: download the publication; DOAB: description of the publication

Résumé

The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.

Description matérielle

1 electronic resource (226 p.)

ISBN

books978-3-03921-777-9
9783039217762
9783039217779

Accès

Open Access