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In-Cell NMR Spectroscopy: Biomolecular Structure and Function

This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technol...

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Bibliografische gegevens
Hoofdauteur: Burz, David S. (auth)
Andere auteurs: Shekhtman, Alexander (auth)
Formaat: Elektronisch Hoofdstuk
Taal:Engels
Gepubliceerd in: MDPI - Multidisciplinary Digital Publishing Institute 2020
Onderwerpen:
Biology, life sciences
protein NMR
time-resolved NMR
Ribosome
structural calculation 4
crystalline and amorphous starch
in-cell NMR
protein dynamics
DNP
protein modification
Tau
spectrum reconstruction 3
mRNA
Thioredoxin
protein structure
protein interactions
drug discovery
protein structure determination 1
review
enzyme activity
MARK2 phosphorylation
post-translational modifications
Dihydrofolate reductase
mammalian cells
target engagement
non-uniform sampling 2
paramagnetic effects
protein structure-function
cross-correlated relaxation
structure function
rRNA
2D INADEQUATE
lipid membrane
Thymidylate synthase
whole cell NMR
enzyme kinetics
magic-angle spinning
live cell
solid-state NMR
Adenylate kinase
DNA
in-situ NMR
antimicrobial peptide
NMR spectroscopy
intrinsically disordered proteins
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Omschrijving
Samenvatting:This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.]
Fysieke beschrijving:1 electronic resource (152 p.)
ISBN:books978-3-03928-255-5
9783039282555
9783039282548
Toegang:Open Access

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