Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications

• Κύριος συγγραφέας: Megan Chircop (auth)
• Άλλοι συγγραφείς: Daniel Speidel (auth)
• Μορφή: Ηλεκτρονική πηγή Κεφάλαιο βιβλίου
• Γλώσσα: Αγγλικά
• Έκδοση: Frontiers Media SA 2015
• Σειρά: Frontiers Research Topics
• Θέματα: Medicine; DNA Repair; DNA Damage; tumorigenesis; therapeutic targets; chemotherapy; Apoptosis; cellular stress; therapy resistance
• Διαθέσιμο Online: DOAB: download the publication; DOAB: description of the publication

In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or...