Myelin-Mediated Inhibition of Axonal Regeneration: Past, Present, and Future

• Main Author: Wilfredo Mellado (auth)
• Other Authors: Sari Hannila (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Neurosciences; MAG; Omgp; axonal regeneration; myelin-associated inhibitors; CNS regeneration; Nogo; cAMP
• Online Access: DOAB: download the publication; DOAB: description of the publication

Pioneering studies conducted in the 1980's laid the foundation for the hypothesis that axonal regeneration is limited by CNS myelin, and the identification of myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein (OMgp) as inhibitors of neurite outgrowth firmly est...