The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance

• Main Author: Geraldo Aleixo Passos (auth)
• Other Authors: Ernna Herida Oliveira (auth), Daniella Areas Mendes-da-Cruz (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Medicine; thymic crosstalk; Central Tolerance; promiscuous gene expression; Aire gene; cell-cell interaction; thymocyte; microRNA; Thymic B cell; Chemokines; Thymus
• Online Access: DOAB: download the publication; DOAB: description of the publication

The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mT...