Role of DNA Methyltransferases in the Epigenome

• Main Author: Jeltsch, Albert (auth)
• Other Authors: Gowher, Humaira (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Biology, life sciences; DNMTs; n/a; histone modification; TBRS; DNA methyltransferases; autoinhibition; epigenetics; DNMT; cell identity; embryogenesis; dwarfism; DNMT3B; germ cells; HSAN1E; USP7; DNMT3A; DNA methyltransferase; gene expression; DNMT1; de novo DNA methylation; DNA methyltransferase structure; UHRF1; DNA methyltransferase mechanism; allosteric regulation; rare diseases; DNA Methylation; maintenance DNA methylation; DNA methylation; ADCA-DN; PCC/PGL; ubiquitination; TETs; DNA methyltransferase function; molecular epigenetics; DNA methyltransferase regulation
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors

Physical Description

1 electronic resource (150 p.)

ISBN

books978-3-03928-021-6
9783039280216
9783039280209

Access

Open Access