Insulin-Like Growth Factors in Development, Cancers and Aging

• Otros Autores: Werner, Haim (Editor)
• Formato: Electrónico Capítulo de libro
• Lenguaje: inglés
• Publicado: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Materias: Research & information: general; Biology, life sciences; IGF-I; IGF-II; insulin; IGF-IR; IRs; tyrosine kinase receptor; GPCRs; hybrids; phosphorylation; G-proteins; β-arrestins; functional RTK/GPCR hybrid; nuclear translocation; IGF-I receptor; signaling; targeted therapeutics; IGF-Trap; IGF system; IGFBP-3; IGFBP-3R; TMEM219; anti-tumor; anti-metastatic; agonists; mAb therapy; IGF-1; IGFBP-1; older adults; longevity; health-span; age-related disease; cognitive impairment; diabetes; mitochondria; growth hormone; insulin-like growth factor-1; aging; oxidative stress; senescence; longitudinal study; IGFBP; mouse models; skeletal muscle; MSCs; myogenesis; glucose regulated protein (GRP) 94; insulin-like growth factor; obligate chaperone; hypertrophy; atrophy; cachexia; muscle regeneration; autophagy; IGF-1R; insulin receptor; IR-A; structural studies; receptor activation; n/a
• Acceso en línea: DOAB: download the publication; DOAB: description of the publication

Sumario

This Special Issue of Cells on "Insulin-Like Growth Factors in Development, Cancers and Aging" provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners.

Descripción Física

1 electronic resource (196 p.)

ISBN

books978-3-0365-0771-2
9783036507705
9783036507712

Acceso

Open Access