Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss

• Egile Nagusiak: Chong Cui (Egilea), Daqi Wang (Egilea), Bowei Huang (Egilea), Fang Wang (Egilea), Yuxin Chen (Egilea), Jun Lv (Egilea), Luping Zhang (Egilea), Lei Han (Egilea), Dong Liu (Egilea), Zheng-Yi Chen (Egilea), Geng-Lin Li (Egilea), Huawei Li (Egilea), Yilai Shu (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9 tools. However, it is difficult to precisely assess the editing performance in vivo because the tissues contain many non-targeted cells, which is one of the major barriers to clinical translation. Here, in the A...