Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.

• Egile Nagusiak: Beatriz Álvarez-Rodríguez (Egilea), Christian Tiede (Egilea), Alexis C R Hoste (Egilea), Rebecca A Surtees (Egilea), Chi H Trinh (Egilea), Gillian S Slack (Egilea), John Chamberlain (Egilea), Roger Hewson (Egilea), Alba Fresco (Egilea), Patricia Sastre (Egilea), Darren C Tomlinson (Egilea), Paul A Millner (Egilea), Thomas A Edwards (Egilea), John N Barr (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2020-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. We describe the selection of a high-affinity small protein (Affimer-NP) that binds specifically to the nucleopr...