Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.

• Main Authors: Beatriz Álvarez-Rodríguez (Author), Christian Tiede (Author), Alexis C R Hoste (Author), Rebecca A Surtees (Author), Chi H Trinh (Author), Gillian S Slack (Author), John Chamberlain (Author), Roger Hewson (Author), Alba Fresco (Author), Patricia Sastre (Author), Darren C Tomlinson (Author), Paul A Millner (Author), Thomas A Edwards (Author), John N Barr (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. We describe the selection of a high-affinity small protein (Affimer-NP) that binds specifically to the nucleopr...