The Protective Effect of Radicicol Against Renal Ischemia-Reperfusion Injury in Mice

• Main Authors: Hiroko Sonoda (Author), Worapat Prachasilchai (Author), Hiroaki Kondo (Author), Naoko Yokota-Ikeda (Author), Sayaka Oshikawa (Author), Katsuaki Ito (Author), Masahiro Ikeda (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia-reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Trea...