An Effective Sodium-Dependent Glucose Transporter 2 Inhibition, Canagliflozin, Prevents Development of Hypertensive Heart Failure in Dahl Salt-Sensitive Rats

• Auteurs principaux: Lili He (Auteur), Sai Ma (Auteur), Qingjuan Zuo (Auteur), Guorui Zhang (Auteur), Zhongli Wang (Auteur), Tingting Zhang (Auteur), Jianlong Zhai (Auteur), Yifang Guo (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background: The aim of the study was to investigate the protective effect of canagliflozin (CANA) on myocardial metabolism and heart under stress overload and to further explore its possible molecular mechanism.Methods: High-salt diet was used to induce heart failure with preserved ejection fraction...