An Effective Sodium-Dependent Glucose Transporter 2 Inhibition, Canagliflozin, Prevents Development of Hypertensive Heart Failure in Dahl Salt-Sensitive Rats

• Váldodahkkit: Lili He (Dahkki), Sai Ma (Dahkki), Qingjuan Zuo (Dahkki), Guorui Zhang (Dahkki), Zhongli Wang (Dahkki), Tingting Zhang (Dahkki), Jianlong Zhai (Dahkki), Yifang Guo (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Background: The aim of the study was to investigate the protective effect of canagliflozin (CANA) on myocardial metabolism and heart under stress overload and to further explore its possible molecular mechanism.Methods: High-salt diet was used to induce heart failure with preserved ejection fraction...