Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cells.

• Autores principales: Bárbara Hissa (Autor), Jacqueline G Duarte (Autor), Ludmila F Kelles (Autor), Fabio P Santos (Autor), Helen L del Puerto (Autor), Pedro H Gazzinelli-Guimarães (Autor), Ana M de Paula (Autor), Ubirajara Agero (Autor), Oscar N Mesquita (Autor), Cristina Guatimosim (Autor), Egler Chiari (Autor), Luciana O Andrade (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

BACKGROUND: Trypomastigotes of Trypanosoma cruzi are able to invade several types of non-phagocytic cells through a lysosomal dependent mechanism. It has been shown that, during invasion, parasites trigger host cell lysosome exocytosis, which initially occurs at the parasite-host contact site. Acid...