Membrane cholesterol regulates lysosome-plasma membrane fusion events and modulates Trypanosoma cruzi invasion of host cells.

• Main Authors: Bárbara Hissa (Author), Jacqueline G Duarte (Author), Ludmila F Kelles (Author), Fabio P Santos (Author), Helen L del Puerto (Author), Pedro H Gazzinelli-Guimarães (Author), Ana M de Paula (Author), Ubirajara Agero (Author), Oscar N Mesquita (Author), Cristina Guatimosim (Author), Egler Chiari (Author), Luciana O Andrade (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Trypomastigotes of Trypanosoma cruzi are able to invade several types of non-phagocytic cells through a lysosomal dependent mechanism. It has been shown that, during invasion, parasites trigger host cell lysosome exocytosis, which initially occurs at the parasite-host contact site. Acid...