Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody

• Hauptverfasser: Arthur J. Schick (Verfasst von), Victor Lundin (Verfasst von), Justin Low (Verfasst von), Kun Peng (Verfasst von), Richard Vandlen (Verfasst von), Aaron T. Wecksler (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Anti-drug antibodies (ADA) can limit the efficacy and safety of therapeutic antibodies. However, determining the exact nature of ADA interactions with the target drug via epitope mapping is challenging due to the polyclonal nature of the IgG response. Here, we demonstrate successful proof-of-concept...