Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody

• Main Authors: Arthur J. Schick (Author), Victor Lundin (Author), Justin Low (Author), Kun Peng (Author), Richard Vandlen (Author), Aaron T. Wecksler (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anti-drug antibodies (ADA) can limit the efficacy and safety of therapeutic antibodies. However, determining the exact nature of ADA interactions with the target drug via epitope mapping is challenging due to the polyclonal nature of the IgG response. Here, we demonstrate successful proof-of-concept...