Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

• मुख्य लेखकों: Seyung S. Chung (लेखक), Yong Wu (लेखक), Quincy Okobi (लेखक), Debbie Adekoya (लेखक), Mohammad Atefi (लेखक), Orette Clarke (लेखक), Pranabananda Dutta (लेखक), Jaydutt V. Vadgama (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2017-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like. Combined treatment of IL-6 and TNF-α phosphorylated transcription factors STAT3 in a s...