Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

• Asıl Yazarlar: Seyung S. Chung (Yazar), Yong Wu (Yazar), Quincy Okobi (Yazar), Debbie Adekoya (Yazar), Mohammad Atefi (Yazar), Orette Clarke (Yazar), Pranabananda Dutta (Yazar), Jaydutt V. Vadgama (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Hindawi Limited, 2017-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF-α, activated colorectal cancer cells to be more invasive and stem-like. Combined treatment of IL-6 and TNF-α phosphorylated transcription factors STAT3 in a s...