Mild Crigler-Najjar Syndrome with Progressive Liver Disease-A Multicenter Retrospective Cohort Study

• Main Authors: Norman Junge (Author), Hanna Hentschel (Author), Dorothee Krebs-Schmitt (Author), Amelie Stalke (Author), Eva-Doreen Pfister (Author), Björn Hartleben (Author), Martin Claßen (Author), Alexander Querfurt (Author), Veronika Münch (Author), Philip Bufler (Author), Jun Oh (Author), Enke Grabhorn (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Crigler-Najjar Syndrome (CNS) with residual activity of UDP-glucuronosyltransferase 1A1 (<i>UGT1A1</i>) and no need for daily phototherapy is called mild Crigler-Najjar Syndrome. Most of these patients need medical treatment for enzyme induction (phenobarbital) to lower blood levels of u...