Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

• Main Authors: Zhao Wang (Author), Heng Zhang (Author), Zhen Gao (Author), Zihao Sang (Author), Erik De Clercq (Author), Christophe Pannecouque (Author), Dongwei Kang (Author), Peng Zhan (Author), Xinyong Liu (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With our continuous endeavors in seeking potent anti-HIV-1 agents, we reported here the discovery, biological characterization, and druggability evaluation of a class of nonnucleoside reverse transcriptase inhibitors. To fully explore the chemical space of the NNRTI-binding pocket, novel series of d...