Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

• Autores principales: Zhao Wang (Autor), Heng Zhang (Autor), Zhen Gao (Autor), Zihao Sang (Autor), Erik De Clercq (Autor), Christophe Pannecouque (Autor), Dongwei Kang (Autor), Peng Zhan (Autor), Xinyong Liu (Autor)
• Formato: Libro
• Publicado: Elsevier, 2024-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

With our continuous endeavors in seeking potent anti-HIV-1 agents, we reported here the discovery, biological characterization, and druggability evaluation of a class of nonnucleoside reverse transcriptase inhibitors. To fully explore the chemical space of the NNRTI-binding pocket, novel series of d...