Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants

• Egile Nagusiak: Zhao Wang (Egilea), Heng Zhang (Egilea), Zhen Gao (Egilea), Zihao Sang (Egilea), Erik De Clercq (Egilea), Christophe Pannecouque (Egilea), Dongwei Kang (Egilea), Peng Zhan (Egilea), Xinyong Liu (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2024-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

With our continuous endeavors in seeking potent anti-HIV-1 agents, we reported here the discovery, biological characterization, and druggability evaluation of a class of nonnucleoside reverse transcriptase inhibitors. To fully explore the chemical space of the NNRTI-binding pocket, novel series of d...