Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

• Hoofdauteurs: Hiroyuki Mizuguchi (Auteur), Kenji Kawabata (Auteur), Fuminori Sakurai (Auteur), Kazufumi Katayama (Auteur), Mitsuhiro Machitani (Auteur), Kahori Shimizu (Auteur), Tomoko Yamaguchi (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2011-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vectors. Ad vector-induced production of inflammatory c...