Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

• Main Authors: Hiroyuki Mizuguchi (Author), Kenji Kawabata (Author), Fuminori Sakurai (Author), Kazufumi Katayama (Author), Mitsuhiro Machitani (Author), Kahori Shimizu (Author), Tomoko Yamaguchi (Author)
• Format: Book
• Published: MDPI AG, 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vectors. Ad vector-induced production of inflammatory c...