Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

• Principais autores: Hiroyuki Mizuguchi (Autor), Kenji Kawabata (Autor), Fuminori Sakurai (Autor), Kazufumi Katayama (Autor), Mitsuhiro Machitani (Autor), Kahori Shimizu (Autor), Tomoko Yamaguchi (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2011-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vectors. Ad vector-induced production of inflammatory c...