Solubility enhancement of carvedilol using drug-drug cocrystallization with hydrochlorothiazide

• Main Authors: Shivarani Eesam (Author), Jaswanth S. Bhandaru (Author), Chandana Naliganti (Author), Ravi Kumar Bobbala (Author), Raghuram Rao Akkinepally (Author)
• Formato: Libro
• Publicado: SpringerOpen, 2020-11-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs. Carvedilol (CAR), a nonselective beta/alpha1 blocker, used in the treatment of m...