Solubility enhancement of carvedilol using drug-drug cocrystallization with hydrochlorothiazide

• Prif Awduron: Shivarani Eesam (Awdur), Jaswanth S. Bhandaru (Awdur), Chandana Naliganti (Awdur), Ravi Kumar Bobbala (Awdur), Raghuram Rao Akkinepally (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: SpringerOpen, 2020-11-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Abstract Background Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Cocrystallization is one of the techniques to enhance the hydrophilicity of such drugs. Carvedilol (CAR), a nonselective beta/alpha1 blocker, used in the treatment of m...