Jejunal wall delivery of insulin via an ingestible capsule in anesthetized swine-A pharmacokinetic and pharmacodynamic study

• Main Authors: Mir Hashim (Author), Radhika Korupolu (Author), Baber Syed (Author), Kyle Horlen (Author), Simret Beraki (Author), Padma Karamchedu (Author), Arvinder K. Dhalla (Author), Rodolphe Ruffy (Author), Mir Imran (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Biotherapeutic agents must be administered parenterally to obtain therapeutic blood concentrations, lowering patient compliance and complicating care. An oral delivery platform (ODP) was developed to deliver drugs into the small intestinal wall. This proof‐of‐concept study was performed in...