Jejunal wall delivery of insulin via an ingestible capsule in anesthetized swine-A pharmacokinetic and pharmacodynamic study

• Hauptverfasser: Mir Hashim (Verfasst von), Radhika Korupolu (Verfasst von), Baber Syed (Verfasst von), Kyle Horlen (Verfasst von), Simret Beraki (Verfasst von), Padma Karamchedu (Verfasst von), Arvinder K. Dhalla (Verfasst von), Rodolphe Ruffy (Verfasst von), Mir Imran (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2019-10-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Biotherapeutic agents must be administered parenterally to obtain therapeutic blood concentrations, lowering patient compliance and complicating care. An oral delivery platform (ODP) was developed to deliver drugs into the small intestinal wall. This proof‐of‐concept study was performed in...