New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system

• Main Authors: Laura Micheli (Author), Stefania Nobili (Author), Elena Lucarini (Author), Alessandra Toti (Author), Francesco Margiotta (Author), Clara Ciampi (Author), Daniel Venturi (Author), Lorenzo Di Cesare Mannelli (Author), Carla Ghelardini (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Growing evidence suggests that opioid analgesics modulate angiogenesis during pathophysiological processes. Vascular endothelial growth factor-A (VEGF-A) was recently proposed to be involved in pain development. To date, no anti-angiogenic drug is used for pain management. When administered in a bio...