New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system

• المؤلفون الرئيسيون: Laura Micheli (مؤلف), Stefania Nobili (مؤلف), Elena Lucarini (مؤلف), Alessandra Toti (مؤلف), Francesco Margiotta (مؤلف), Clara Ciampi (مؤلف), Daniel Venturi (مؤلف), Lorenzo Di Cesare Mannelli (مؤلف), Carla Ghelardini (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2024-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Growing evidence suggests that opioid analgesics modulate angiogenesis during pathophysiological processes. Vascular endothelial growth factor-A (VEGF-A) was recently proposed to be involved in pain development. To date, no anti-angiogenic drug is used for pain management. When administered in a bio...