Pharmacogenomics polygenic risk score: Ready or not for prime time?

• Main Authors: Sonal Singh (Author), Gabriele Stocco (Author), Katherine N. Theken (Author), Alyson Dickson (Author), QiPing Feng (Author), Jason H. Karnes (Author), Jonathan D. Mosley (Author), Nihal El Rouby (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Pharmacogenomic Polygenic Risk Scores (PRS) have emerged as a tool to address the polygenic nature of pharmacogenetic phenotypes, increasing the potential to predict drug response. Most pharmacogenomic PRS have been extrapolated from disease‐associated variants identified by genome wide ass...