Optimization of In Vivo Electroporation Conditions and Delivery of DNA Vaccine Encoding SARS-CoV-2 RBD Using the Determined Protocol

• Main Authors: Denis Nikolaevich Kisakov (Author), Lyubov Alexandrovna Kisakova (Author), Maria Borisovna Borgoyakova (Author), Ekaterina Vladimirovna Starostina (Author), Oleg Svyatoslavovich Taranov (Author), Elena Konstantinovna Ivleva (Author), Oleg Viktorovich Pyankov (Author), Anna Vladimirovna Zaykovskaya (Author), Dmitry Nikolaevich Shcherbakov (Author), Andrey Pavlovich Rudometov (Author), Nadezda Borisovna Rudometova (Author), Natalia Vyacheslavovna Volkova (Author), Vadim Nikolaevich Gureev (Author), Alexander Alexeyevich Ilyichev (Author), Larisa Ivanovna Karpenko (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vaccination against SARS-CoV-2 and other viral infections requires safe, effective, and inexpensive vaccines that can be rapidly developed. DNA vaccines are candidates that meet these criteria, but one of their drawbacks is their relatively weak immunogenicity. Electroporation (EP) is an effective w...