A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo

• Autores principales: Yi-Wen Wu (Autor), Kai-Cheng Hsu (Autor), Hsueh-Yun Lee (Autor), Tsui-Chin Huang (Autor), Tony E. Lin (Autor), Yi-Ling Chen (Autor), Ting-Yi Sung (Autor), Jing-Ping Liou (Autor), Wendy W. Hwang-Verslues (Autor), Shiow-Lin Pan (Autor), Wei-Chun HuangFu (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment of high metastasis and advanced malignancies. Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacetylase (HDAC) 6 and tubulin assembly. Our data demon...