A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo

• Main Authors: Yi-Wen Wu (Author), Kai-Cheng Hsu (Author), Hsueh-Yun Lee (Author), Tsui-Chin Huang (Author), Tony E. Lin (Author), Yi-Ling Chen (Author), Ting-Yi Sung (Author), Jing-Ping Liou (Author), Wendy W. Hwang-Verslues (Author), Shiow-Lin Pan (Author), Wei-Chun HuangFu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment of high metastasis and advanced malignancies. Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacetylase (HDAC) 6 and tubulin assembly. Our data demon...